High‐dose cytosine arabinoside for acute nonlymphocytic leukemia
作者:
Guy Cantin,
James K. Brennan,
期刊:
American Journal of Hematology
(WILEY Available online 1984)
卷期:
Volume 16,
issue 1
页码: 59-66
ISSN:0361-8609
年代: 1984
DOI:10.1002/ajh.2830160108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: acute nonlymphocytic leukemia;cytosine arabinoside;complete remission;induction chemotherapy
数据来源: WILEY
摘要:
AbstractEighteen patients with acute nonlymphocytic leukemia (ANLL), aged 17–73 years, were treated with high‐dose cytosine arabinoside (HD‐Ara‐C)) using 3 g/m2IV q 12 hours × 12 doses. Seven patients were treated for relapse and four (57%) obtained a complete remission with a median duration of 19.5 weeks. In nine patients, refractory to conventional chemotherapy, no complete responders were observed. Treatment failure was most commonly due to drug resistance. Two elderly patients with ANLL not previously exposed to chemotherapy died during the initial induction. Recent data on the HD‐Ara‐C experience in ANLL are presented and compared wit
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