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Assignment of proteins to human chromosome 21 using two-dimensional gel electrophoresis and somatic cell genetics: An approach to the study of Down syndrome

 

作者: DevineEvelyn A.,   BrownW. Ted,   JenkinsEdmund C.,   DutkowskiRegina,   SammonsDavid,  

 

期刊: Journal of Neurogenetics  （Taylor Available online 1987）
卷期: Volume 4, issue 3  

页码: 215-226

 

ISSN:0167-7063

 

年代: 1987

 

DOI:10.3109/01677068709167182

 

出版商: Taylor&Francis

 

关键词: Trisomy 21;Two-dimensional gel electrophoresis;Somatic cell genetics;Protein mapping;In situ hybridization

 

数据来源: Taylor

 

摘要:

A mouse hybrid cell line (WA17d) was derived which contained multiple copies of human chromosome 21 and no other human chromosome. Cell extracts of this line were prepared and subjected to two-dimensional gel electrophoresis. Several proteins were identified whose synthesis was altered by the presence of chromosome 21 and 6 proteins were identified as being specific to this human chromosome. These gene products might be involved in the pathogenesis of Down syndrome and be related to the neurologic defects and premature aging seen in this common chromosome abnormality.

 

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