Electrochemistry and Detection of Some Organic and Biological Molecules at Conducting Polymer Electrodes. II. Effect of Nature of Polymer Electrode and Substrate on Electrochemical Behavior and Detection of Some Neurotransmitters
作者:
Ahmed Galal,
NadaF. Atta,
JudithF. Rubinson,
Hans Zimmer,
HarryB. Mark,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 7
页码: 1361-1381
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308017418
出版商: Taylor & Francis Group
关键词: Electrochemistry;Biological Compounds;HPLC;Detection;Conducting Polymers;Electrocatalysis;Sensors;Neurotransmitters
数据来源: Taylor
摘要:
The electrochemical behavior and detection of some molecules of biological significance were studied. The separation and detection of some neurotransmitters, namely, norepinephrine, L-DOPA, epinephrine, and dopamine were accomplished using reverse phase high performance liquid chromatography(HPLC) and amperometric detection, respectively. The voltammetric behavior of these molecules was compared using different polymeric electrodes. Electrocatalytic “efficiency” decreases in the order of poly(3-methylthiophene)(P3MT), poly(N-methylpyrrole)(PNMP), poly(aniline)(PAn) and poly(furan)(PF). P3MT showed improved performance as an amperometric detector for HPLC analysis systems over other types of polymer and conventional electrodes examined. Detection limits as low as 10−8-10−9M were achieved using the P3MT, compared to 10−6-10−8M using glassy carbon or platinum electrodes. The nature of the substrate used for the polymer deposition had no effect on the electrochemical characteristics of the compounds studied. The results describes the intrinsic catalytic property of the polymer electrode surface towards the redox behavior of the compounds studied. The polymer electrode showed promising antifouling resistant against common fouling agents.
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