Retinoids—“Differentiation Agents” for Cancer Treatment and Prevention
作者:
SANDRA HOFMANN,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1992)
卷期:
Volume 304,
issue 3
页码: 202-213
ISSN:0002-9629
年代: 1992
出版商: OVID
关键词: Retinoids;Acute promyelocytic leukemia;Chemoprevention;Differentiation.
数据来源: OVID
摘要:
The ability of vitamin A and its derivatives to induce differentiation in certain target tissues has been appreciated for nearly a century. Recently, oral all-trans retinoic acid (ATRA), a vitamin A metabolite, has been shown to induce terminal differentiation of leukemic cells in patients with acute promyelocytic leukemia (APL). Complete remissions are obtained and normal hematopoiesis is established in an outpatient setting with minimal side effects in the majority of cases. Although remissions are not durable, disseminated intravascular coagulation, a frequent complication of remission induction in APL, is avoided by oral ATRA prior to definitive chemotherapy. The molecular basis for the efficacy of ATRA in APL appears to be the involvement of the retinoic acid receptor α locus in the t(15;17) translocation breakpoint characteristic of APL.
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