Application of Derivative and Ratio Spectra Derivative Spectrophotometry for the Determination of Pseudoephedrine Hydrochloride and Acrivastine in Capsules
作者:
Erdal Dinç,
Feyyaz Onur,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 6
页码: 1179-1191
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708004047
出版商: Taylor & Francis Group
关键词: acrivastine;pseudoephedrine hydrochloride;simultaneous determination;pharmaceutical formulation;derivative spectrophotometry;ratio spectra derivative spectrophotometry
数据来源: Taylor
摘要:
Two new spectrophotometric methods are used for the determination of acrivastine and pseudoephedrine hydochloride in their mixture without previous chemical separation. In the first, second derivative spectrophotometry, the measurements are made at 288.0 nm for acrivastine and at 270.2 nm for pseudoephedrine hydrochloride in the second derivative spectra of their solution in 0.1M NaOH. In the second, ratio spectra derivative spectrophotometry, the amplitudes are measured at 276.0 nm and 298.5 nm corresponding to two maximums for acrivastine, and at 252.6 nm and 268.3 nm corresponding to a maximum and a minumum, respectively, for pseudoephedrine hydrochloride in first derivative of their ratio spectra plotted by using of their solutions as divisor. The methods were successfully applied for the determination of these drugs in a commercial pharmaceutical formulation capsule.
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