Preparation and fungitoxicity of 3-bromo-6-chloro- and 6-bromo-3-chloro-8-quinolinols
作者:
H.Gershon,
D.D.Clarke,
M.Gershon,
期刊:
Monatshefte für Chemie / Chemical Monthly
(Springer Available online 2004)
卷期:
Volume 127,
issue 3
页码: 331-337
ISSN:0026-9247
年代: 2004
DOI:10.1007/BF00813800
出版商: Springer_Vienna-Vienna
数据来源: Springer
摘要:
3-Bromo-6-chloro- and 6-bromo-3-chloro-8-nitro, -8-amino-, and -8-hydroxyquinolines along with 3-bromo- and 3-chloroquinolin-6,8-diols were prepared and tested for antifungal activity against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, Trichophyton mentagrophytes) inSabourauddextrose broth. Compounds with chlorine in the 3 position were generally more fungitoxic than the corresponding analogues with bromine. 6-Bromo-3-chloro-8-quinolinol inhibited four fungi at levels below 1 µg/ml andA. nigerandM. cirinelloidesat 2 µg/ml eac
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