Acute Pharmacodynamic Effects of GlucocorticoidsCardiac Output and Related Hemodynamic Changes in Normal Subjects and Patients in Shock
作者:
Mohinder Sambhi,
Max Weil,
Vasant Udhoji,
期刊:
Circulation
(OVID Available online 1965)
卷期:
Volume 31,
issue 4
页码: 523-530
ISSN:0009-7322
年代: 1965
出版商: OVID
数据来源: OVID
摘要:
Cardiac output and intravascular pressure were measured before and after large doses of glucocorticosteroids administered intravenously to nine normal subjects and nine patients in shock. Glucocorticoids caused a sustained increase in cardiac output and a decrease in calculated peripheral resistance. No changes in mean arterial and venous pressures were observed. Possible mechanisms underlying these pharmacologic effects and their implications for the treatment of shock are discussed.
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