Hemoglobin Mizuho or Beta 68 (E 12) Leucine→Proline, a new Ufistarle Variaiit Associated with Severe Hemolytic Anemia
作者:
OhbaY.,
MiyajiT.,
MatsuokaM.,
SugiyamaK.,
SuzukiT.,
SugiuraT.,
期刊:
Hemoglobin
(Taylor Available online 1977)
卷期:
Volume 1,
issue 5
页码: 467-477
ISSN:0363-0269
年代: 1977
DOI:10.3109/03630267709027864
出版商: Taylor&Francis
数据来源: Taylor
摘要:
A hitherto undescribed, unstable hemoglobin was discovered in a four-year-old Japanese girl with relatively severe hemolytic anemia requiring monthly blood transfusion Although no abnormal hemoglobin was detectable by electrophoresis at pll 8.6 and 7.0, heat denaturation and isopropanol tests gave positive results.Chemical analyses of the heat labile henioglohin have demonstrated an amino acid substitution of a prolyl for the leucyl residue at the 68th (E 12) position.Remarkable clinical improvement was observed after splenectomy.
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