The purpose of this investigation was to develop routine methods for qualitative and quantitative analyses of the monomers in dental resin and composite materials. The content of inorganic fillers was determined by combustion analysis. Total filler content of the so-called microfill materials was determined after removing the monomers and additives by means of a solvent.The monomers were determined qualitatively and quantitatively by means of high performance liquid chromatography. The components in the liquid resin systems were separated by adsorption, partition and gel permeation chromatography. Semi-preparative columns were used for separation of unknown monomers. The fractions were analyzed by means of infrared spectroscopy, mass spectrometry, proton and carbon thirteen magnetic resonance spectroscopy.This investigation demonstrates the variety in composition of dental resin and composite materials.