High Percentage of Seronegative HCV Infections in Hemodialysis Patients: The Need for PCR
作者:
Matthias Schröter,
Heinz-Hubert Feucht,
Peter Schäfer,
Bernhard Zöllner,
Rainer Laufs,
期刊:
Intervirology
(Karger Available online 1997)
卷期:
Volume 40,
issue 4
页码: 277-278
ISSN:0300-5526
年代: 1997
DOI:10.1159/000150558
出版商: S. Karger AG
关键词: Hepatitis C virus;Hepatitis C;Hemodialysis;Polymerase chain reaction;Seroconversion
数据来源: Karger
摘要:
Among patients undergoing maintenance hemodialysis, a high prevalence of hepatitis C virus (HCV) infection can be observed. In a prospective study, sera of 273 patients were examined for the presence of HCV infection by serological tests and by PCR. Thirty-five patients (12.8%) were HCV antibody positive, and in 31 of them HCV RNA could be detected by PCR. Among the 238 seronegative patients HCV infection was detected in 12 cases (5.0%) exclusively by PCR. Only in 1 of these patients seroconversion could be observed within the 18-month follow-up period. These findings demonstrate that in hemodialysis patients PCR is necessary for the diagnosis of HCV infection.
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