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Plasma Levels of Cyclic GMP, Immune Parameters and Depressive Status during Interferon Therapy

 

作者: Ariyuki Kagaya,   Yosuke Uchitomi,   Eiichi Takezaki,   Mayumi Fukue,   Ken Tsukano,   Akira Kugaya,   Hideaki Minagawa,   Minoru Takebayashi,   Hidenobu Zensho,   Takahiro Oyamada,   Shigeto Yamawaki,  

 

期刊: Neuropsychobiology  （Karger Available online 1997）
卷期: Volume 35, issue 3  

页码: 128-131

 

ISSN:0302-282X

 

年代: 1997

 

DOI:10.1159/000119333

 

出版商: S. Karger AG

 

关键词: Interferon;Cyclic GMP;Soluble interleukin-2 receptor;Depression

 

数据来源: Karger

 

摘要:

In this report, we investigated the relationship between depressive symptoms and plasma interferon (IFN)-α-like immunoreactivity, cyclic GMP (cGMP) and soluble interleukin-2 receptor (sIL-2R) levels during IFN therapy. An altered mood state was observed in 5 of 26 patients. IFN-α-like immunoreactivity in the depressed group tended to be elevated. cGMP levels of depressed patients were significantly greater than those of control subjects before and 6 weeks after IFN therapy. However, sIL-2R levels were not different between the two groups. These results suggest that a number of patients suffered from depression during IFN therapy and that patients had greater concentrations of cGMP level

 

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