Distribution of Drugs over Whole BloodI. The Transport Function of Whole Blood for Valproate
作者:
O. Driessen,
L. Treuren,
J. Meijer,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 4
页码: 384-389
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Valproate;Erythrocytes;Plasma proteins;Ultrafiltrates.
数据来源: OVID
摘要:
Summary:A method is presented for the determination of valproate (VPA) in ˜40 &mgr;l erythrocyte concentrations. Valproate partition between plasma proteins, ultrafiltrate, and erythrocytes at various concentrations was studied in vitro and in vivo. Partition ratios depended on VPA concentration in whole blood and the ratio of erythrocytes/ultrafiltrate, which increased with rising concentrations in the ultrafiltrate fraction. Shifts in ratios were studied by expanding the ultrafiltrate fraction of VPA‐spiked blood. It appeared that VPA delivery to the expanded ultrafiltrate compartment originated in a disproportionately large part from erythrocytes. In vivo the half‐life of VPA in the erythrocyte fraction was 0.7 h, whereas in the ultrafiltrate fraction and proteinbound fraction half‐lives of 2 and 5 h were observed. It is concluded that for VPA in relation to erythrocytes a “last‐come‐first‐go” system is plausible.
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