Lack of Antiandrogenic Effects of Topical Bifonazole on Sebaceous Glands and Hairs in the Hamster Flank Organ
作者:
Mario Aricò,
Giuseppe Noto,
Gabriella Pravatà,
Maria R. Bongiorno,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1993)
卷期:
Volume 6,
issue 1
页码: 52-55
ISSN:1660-5527
年代: 1993
DOI:10.1159/000211086
出版商: S. Karger AG
关键词: Bifonazole;Antiandrogen;Flank organ
数据来源: Karger
摘要:
The activity of topically applied bifonazole was evaluated in vivo in the three androgen-dependent structures of the hamster flank organ, i.e. the pigmented spot, sebaceous glands and hairs. Topical bifonazole in our experience did not demonstrate any morphological effect on sebaceous gland and hair even when applied in the dosage of 3 mg/cm2/day. On the basis of our morphometric results we can conclude that topically applied bifonazole does not interfere with cutaneous androgen metabolic transformations in the pilosebaceous unit of the flank organ.
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