The northern pike, Esox lucius, is a ready source of food in many arctic and subarctic areas of North America. Because little information is available concerning lipids in fresh-water fish a study was made of these substances in the northern pike. Specimens were caught on hooks in Lake Minchumina, Alaska. Blood and liver were analyzed for fatty acids, sterols, and phospholipids. The pike is distinctive in having a rather high liver cholesterol–0.89 percent of fresh tissue. The other lipids are not unique but fall into the pattern for animals previously studied. However, marine fish in general have consistently more fat in the liver than does the northern pike.