Vinblastine‐Induced Erythrocytotoxicity
作者:
Alan J. Neville,
Carol A. Rand,
Ronald D. Barr,
期刊:
Scandinavian Journal of Haematology
(WILEY Available online 1982)
卷期:
Volume 28,
issue 1
页码: 32-38
ISSN:0036-553X
年代: 1982
DOI:10.1111/j.1600-0609.1982.tb02117.x
出版商: Blackwell Publishing Ltd
关键词: erythrocytotoxicity;vinblastine
数据来源: WILEY
摘要:
At a therapeutic concentration (10−6mol/l), vinblastine causes no significant changes of erythrocyte morphology in whole blood in vitro, but, with 30% red cell suspensions in buffer, the drug is stomatocytogenic. Several pathogenetic mechanisms are considered and the clinical relevance of this finding is assesse
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