TheIn SituExpression of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) mRNA at the Maternal-Fetal Interface
作者:
KanzakiHideharu,
CrainieMary,
LinHui,
YuiJane,
GuilbertLarry J.,
MoriTakahide,
WegmannThomas G.,
期刊:
Growth Factors
(Taylor Available online 1991)
卷期:
Volume 5,
issue 1
页码: 69-74
ISSN:0897-7194
年代: 1991
DOI:10.3109/08977199109000272
出版商: Taylor&Francis
关键词: GM-CSF;mRNA;placenta;decidua;in situ hybridization
数据来源: Taylor
摘要:
AbstractGranulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by cells in the placenta, is known to be a growth factor for trophoblast cells in vitro and when injected into pregnant mice at risk for mid-gestation fetal resorption, dramatically lowers the fetal death rate while stimulating placental and fetal growth. We describe here the localization of GM-CSF mRNA expression in murine placenta by in situ hybridization. It is found in small round cells (lymphoid-like) and endothelial cells in the maternal decidua. In addition, GM-CSF transcripts are located in cells of the spongiotrophoblast zone (trophoblast-like cells), but not in the labyrinthine zone. These results indicate that GM-CSF may be influencing the growth and function of the fetal placenta in a paracrine-autocrine manner. These results support earlier observations that link GM-CSF production during pregnancy to decidual T-lymphocytes and further suggest a placental source within the invasive trophoblast.
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