AbstractWe investigated the possibility of a microwave oven to replace the standard electric oven and water bath in histological staining procedures that require increased temperature. The technical details were perfected using the Perl's stain for tissue iron. We used a temperature probe to regulate and monitor the temperature of the staining solution. This led to the successful modification of the iron staining procedure for use in the microwave oven, resulting in a reduction in incubation time of 80%, compared to the standard oven procedure. We now use the microwave oven in most of our staining procedures that require heating.