Increase of Natural Killer Activity of Mouse Lymphocytes Followingin vitroandin VivoTreatment with Lithium
作者:
FuggettaP. M.,
AlvinoE.,
RomaniL.,
GrohmannU.,
PotenzaC.,
GiulianiA.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1988)
卷期:
Volume 10,
issue 1
页码: 79-91
ISSN:0892-3973
年代: 1988
DOI:10.3109/08923978809014403
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThein vivoandin vitroinfluence of lithium lactate on mouse natural killer activity was investigated.In vitroexposure of effector-target mixture to graded concentrations of lithium did not substantially modify the natural killer activity of mouse splenocytes, untreated or pretreated with cyclophosphamide. Howeverin vitrotreatment of effector splenocytes increased the frequency of NK-percursor cells.Thein vivotreatment with lithium lactate greatly increased the natural killer activity in intact mice, whereas it did not improve this cytotoxic function in host immunodepressed by cyclophosphamide.These data suggest that lithium salts produce a modulation of natural killer activity of mouse spleen cells, probably through a mechanism involving the increase of the number of NK-precursors in hosts not subjected to cytotoxic chemotherapy.
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