Stereoselective Aldol Reactions with α‐Unsubstituted Chiral Enolates
作者:
Manfred Braun,
期刊:
Angewandte Chemie International Edition in English
(WILEY Available online 1987)
卷期:
Volume 26,
issue 1
页码: 24-37
ISSN:0570-0833
年代: 1987
DOI:10.1002/anie.198700241
出版商: Hüthig&Wepf Verlag
关键词: Stereoselective aldol reactions;Aldol reaction;Chiral enolates;Enolates;Synthetic methods
数据来源: WILEY
摘要:
AbstractThe aldol reaction is among the most important methods of forming carbon‐carbon bonds. The addition of an enolate to an aldehyde leads to the formation of at least one chiral center. In the case of α‐substituted enolates it has to a large extent been possible to control the product stereochemistry, while the aldol reaction of α‐unsubstituted chiral enolates was for many years a “problem child” for synthetic chemists because of its insufficient stereoselectivity. Progress in this area has only been made in the last few years using either new chiral auxiliaries or alternatives to the ald
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