Preparation of Mannac Containing Chitooligomers By Isomerisation and their Binding to Nkr-P1 Protein
作者:
Petr Sedmera,
Věra Přikrylová,
Karel Bezouška,
Eva Rajnochová,
Joachim Thiem,
Vladimír Křen,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1998)
卷期:
Volume 17,
issue 9
页码: 1351-1357
ISSN:0732-8303
年代: 1998
DOI:10.1080/07328309808002358
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
4-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-2-acetamido-2-deoxy-D-mannopyranose (2) was prepared from diacetylchitobiose (1) by Lobry de Bruyn-Alberda van Ekenstein rearrangement under catalysis of Ca(OH)2. The disaccharide2shows about ten times higher affinity than1towards NKR-P1 protein acting as a crucial activating receptor of rat natural killer cells (leukocytes). Chitotriose (3) can be epimerized analogously to give GlcNAcβ1-4GlcNAcβ1-4ManNAc (4) and its binding properties to NKR-P1 are also about ten times higher than those of3.
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