AbstractA single i.p. injection of cisplal-in (10 mg/kg body weight) into mice results in a significant increase in chemiluminescence and ATP contents of the peritoneal exudate cells (PEC) than that of PEC from untreated mice. It is also observed that in vitro treatment of macrophages with cisplatin, rIFN-γand LPS show increased activity of the protein kinase-C.(PK-C). the activation of PK-C could result in stimulation of NADPH-oxidase resulting in increased levels of chemi luminescence. Increased contents of ATP in PEC after cisplatin treatment also suggests that this activation is energy dependent.