Induction of cytochrome P-450 in the rabbit eye by phenobarbital, as detected immunohistochemically
作者:
MatsumotoKazuro,
KishidaKenichi,
ManabeReizo,
SugiyamaToshihiro,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 7
页码: 847-854
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709034854
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of intraperitoneal administration of phenobarbital at a dose of 80 mg per kg per day. We did not detect significant immunofluorescence in other ocular tissues. Prolonged administration caused degeneration of the ciliary epithelium, but no pathological change was seen in other ocular tissues. In this case, immunofluorescence was not detected in the ciliary epithelium but in the cornea, conjunctiva and lens.
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