Fungal infections are a significant and growing cause of morbidity and mortality in patients with acquired immunodeficiency syndrome and human immunodeficiency virus. They are often difficult to recognize; treatment often fails to cure. New regimens seeking long-term suppression and prophylaxis have been explored. This article will focus on the developments in the last year involving these major mycotic infections, ie, candidiasis and other superficial mycoses, cryptococcosis, histoplasmosis, blastomycosis, coccidioidomycosis, and aspergillosis.