Correction of the defective extracellular matrix of Ehlers‐Danlos syndrome skin fibroblasts by dexamethasone.
作者:
Laura Moro,
Marina Colombi,
Nicoletta Zoppi,
Annalisa Ghinelli,
Sergio Barlati,
期刊:
Cell Biology International
(WILEY Available online 1994)
卷期:
Volume 18,
issue 1
页码: 29-37
ISSN:1065-6995
年代: 1994
DOI:10.1006/cbir.1994.1004
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractSkin fibroblasts derived from Ehlers‐Danlos syndrome (EDS) patients lack an organized extracellular matrix (ECM) of fibronectin (FN) and often show an accumulation of cytoplasmic FN. The treatment of EDS cells of different types (I to VIII) with 10‐7M dexamethasone (dex), as well as cocultivation with control fibroblasts, induced in most cases the assembly of a FN‐like ECM. The study of FN mRNA expression by dot‐blot hybridization and of FN released into the culture media of EDS cells showed that the correction of the defective FN‐ECM of EDS cells by dex treatment is associated in most cases with an increase of FN mRNA synthesis and of se
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