[K+]outaccelerates inactivation of Shal‐channels responsible for A‐current in rat CA1 neurons
作者:
Yu Kirichok,
A Nikolaev,
O Krishtal,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 625-629
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: A-channels;CA1 pyramidal neurons;Inactivation;Shal-subfamily
数据来源: OVID
摘要:
SOMATO-DENDRITIC subthreshold transient potassium current (ISA) was measured in acutely isolated rat hippocampal CA1 pyramidal neurons. The inactivation of this current was insensitive to externally applied H2O2(20 mM) which causes cysteine oxidation. This result suggests that Shal-channels not Shaker Kv1.4 channels underlie the somato-dendritic ISAin rat CA1 pyramidal neurons. The kinetics of the ISAinactivation was measured at various [K+]out. Increase in [K+]outleads to acceleration of Shal-channel inactivation. Thus, the shift in [K+]outfrom 1 to 50 mM results in decreased inactivation time constant from 37 to 91ms. This effect of [K+]outon the ISAis opposite to the previously described action of [K+]outon the inactivation of Shaker K+channels.
点击下载:
PDF
(349KB)
返 回