Effect of the Opioid Kappa-Receptor Agonist U50488H on the Secretion of Arginine Vasopressin
作者:
Yutaka Oiso,
Yasumasa Iwasaki,
Kunikazu Kondo,
Kensuke Takatsuki,
Akio Tomita,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 6
页码: 658-662
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125078
出版商: S. Karger AG
关键词: Arginine vasopressin;U50488H;Opioid receptors;Diuresis
数据来源: Karger
摘要:
The effect of U50488H, a potent opioid K-receptor agonist, was investigated on the urine volume and on the secretion of arginine vasopressin (AVP) in response to dehydration or hyperosmolar or hypovolemic stimulation in conscious rats. This agonist markedly increased the urine volume in normally hydrated rats and suppressed plasma AVP in a dose-dependent manner in rats given hyperosmolar saline. This suppression of plasma AVP was completely reversed by concurrent injection of naloxone. U50488H also inhibited the release of AVP in dehydrated or hypovolemic rats. These findings indicate that the diuresis induced by U50488H is mainly caused by the suppression of plasma AVP. They also suggest that the K-opioid receptor plays an important role in regulating the secretion of AVP.
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