Depression remains under-recognised and under-treated despite it being more disabling than any other medical disorder and the availability of effective protocol-based psychotherapy and pharmacotherapy treatments. Prevailing psychotherapy seldom employs evidence-based treatments, continuing instead the use of idiosyncratic psychotherapies of dubious value.Computer interview programs have been developed and evaluated that have the potential to make protocol-based psychotherapy of proven efficacy available over the Internet. Interactive voice response (IVR) makes these programs even more accessible through any touch-tone telephone.COPE™ is a self-help program for patients with depression that combines a series of booklets, videotapes and IVR telephone calls. One trial reported significant reductions in Hamilton Depression Rating Scale scores in patients with depression who completed a 12-week COPE™ program.Impediments to dissemination of these computer tools that complement, supplement and reinforce best practice values include developer's limited knowledge of business practices and the slow change of practice paradigms.