首页   按字顺浏览 期刊浏览 卷期浏览 Synthesis of tri‐, tetra‐, and penta‐deuterated forms of vitamin a
Synthesis of tri‐, tetra‐, and penta‐deuterated forms of vitamin a

 

作者: H. Robert Bergen,   Harold C. Furr,   James A. Olson,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1988）
卷期: Volume 25, issue 1  

页码: 11-21

 

ISSN:0362-4803

 

年代: 1988

 

DOI:10.1002/jlcr.2580250103

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Deuterated vitamin A analogues;deuterated retinyl acetate;20,20,20‐2H3‐retinyl acetate;14,20,20,20‐2H4‐retinyl acetate;12,14,20,20,20‐2H5‐retinyl acetate;10,19,19,19‐2H4‐retinyl acetate;retinoid synthesis

 

数据来源: WILEY

 

摘要:

AbstractThe synthesis of 20,20,20‐trideutero, 14,20,20,20‐tetradeutero, 12,14,20,20,20‐pentadeutero, and 10,19,19,19‐tetradeutero analogs of retinoic acid ethyl ester and retinyl acetate, by a modified Wittig‐Horner synthesis, is described. Deuterium was introduced by base‐catalyzed exchange into appropriate intermediates. The 10,19,19,19‐2H4‐vitamin A, because of its high isotopic integrity (>98%2H4), is the preferred analog for biological studies of vitam

 

点击下载:  PDF (401KB)



返 回