The use of synthetic peptides in the study of experimental autoimmune uveitis
作者:
DonosoLarry A.,
GregersonDale S.,
FlingSteven P.,
MerrymanCarmen F.,
SeryTheodore W.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue sup1
页码: 155-161
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999436
出版商: Taylor&Francis
数据来源: Taylor
摘要:
S-antigen is a highly pathogenic retinal autoantigen for the induction of experimental autoimmune uveitis (EAU). EAU is predominately a T cell mediated autoimmune disease of the uveal tract and retina of the eye and the pinealocytes of the pineal gland. Using synthetic peptides it has been possible to identify several B cell and T cell epitopes in the molecule. In addition, synthetic peptides derived from proteins of diverse origin with amino acid sequence homology to pathogenic regions of S-antigen induce an EAU which is indistinguishable from the disease induced by native S-antigen. These studies aid in the understanding of immune mechanisms in EAU and provide a basis for the pathogenesis of uveitis in humans.
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