AbstractThis investigation was designed to test the hypothesis that there is a direct relationship between quantity of innervation and regenerative capacity. This was done by measuring the quantity of innervation in 13 different species of amphibians chosen to represent a spectrum of regenerative abilities. When looking at the five urodele species alone, or when comparing urodeles and eight anuran species, the results show a lack of correlation between regenerative capacity and quantity of innervation. However, if the anurans alone are considered, the four species in which regeneration has been observed all have levels of innervation greater than in the four species that do not regenerate. This suggests the possibility that an adequate quantity of innervation may be a limiting factor for limb regeneration in anurans, but is not a limiting factor in urodeles.