首页   按字顺浏览 期刊浏览 卷期浏览 Synthesis of [2‐14C]dezaguanine mesylate (6‐amino‐1,5‐dihydro‐4H‐imidazo[4,5‐c]pyridin‐...
Synthesis of [2‐14C]dezaguanine mesylate (6‐amino‐1,5‐dihydro‐4H‐imidazo[4,5‐c]pyridin‐4‐one‐6‐14C methanesulfonate), a new antitumor agent

 

作者: Jon D. Hartman,   Vitauts Alks,   C. C. Huang,   P. Dan Cook,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1986）
卷期: Volume 23, issue 1  

页码: 35-44

 

ISSN:0362-4803

 

年代: 1986

 

DOI:10.1002/jlcr.2580230105

 

出版商: John Wiley&Sons, Ltd.

 

关键词: 3‐Deazaguanine mesylate;dezaguanine mesylate;[6‐14C]6‐Amino‐1,5‐dihydroimidazo[4,5‐c]pyridin‐4‐one methanesulfonate;14C;antitumor;methyl 5‐(chloromethyl)‐1H‐imidazole‐4‐carboxylate;hydrochloride

 

数据来源: WILEY

 

摘要:

AbstractDezaguanine mesylate (CI‐908 mesylate, 3‐deazaguanine mesylate, 6‐amino‐1,5‐dihydro‐4H‐imidazo[4,5‐c]pyridin‐4‐one methanesulfonate,7), a new antitumor agent, was labeled in‐the 2‐position by use of a new synthesis to 3‐deazaguanine. Thus, methyl 4‐(hydroxymethyl)‐1‐(triphenylmethyl‐1H‐imidazole‐5‐carboxylate (10) was converted with thionyl chloride to the corresponding chloromethyl‐derivative11, which was treated with [14C]‐potassium cyanide to afford the labeled penultimate intermediate, methyl 5‐(cyanomethyl)‐1H‐imidazole‐4‐carboxylate (12). Ring closure of12with methanolic ammonia and subsequent salt f

 

点击下载:  PDF (385KB)



返 回