首页   按分类浏览 期刊浏览 卷期浏览 INSULIN‐POTENTIATING ACTION OF HUMAN GROWTH HORMONE:
INSULIN‐POTENTIATING ACTION OF HUMAN GROWTH HORMONE:

 

作者: Claire O. Pullin,   Jennifer A. Harcourt,   Frank M. Ng,   JOSEPH BORNSTEIN,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1981）
卷期: Volume 18, issue 3  

页码: 318-323

 

ISSN:0367-8377

 

年代: 1981

 

DOI:10.1111/j.1399-3011.1981.tb02987.x

 

出版商: Blackwell Publishing Ltd

 

关键词: growth hormone fragments;insulin‐potentiating activity;solid‐phase peptide synthesis

 

数据来源: WILEY

 

摘要:

Four peptides from theN‐terminal region of human growth hormone have been synthesized by the solid‐phase method: hGH(6–13), hGH(7–13), hGH(8–13) and hGH(9–13). Although these peptides contain the sensitive ‐Asp‐Asn‐sequence, apparently homogeneous products were obtained by synthesis on polystyrene resin, cleavage by hydrogen fluoride and purification by ion‐exchange chromatography. The insulin‐potentiating activity of these peptides is reported. The data indicates that extension of hGH(9–13) at itsN‐terminus is requi

 

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