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Reactive Oxygen Metabolites Relax the Lamb Ductus Arteriosus by Stimulating Prostaglandin Production

 

作者: Ronald Clyman,   Ola Saugstad,   Françoise Mauray,  

 

期刊: Circulation Research  (OVID Available online 1989)
卷期: Volume 64, issue 1  

页码: 1-8

 

ISSN:0009-7330

 

年代: 1989

 

出版商: OVID

 

关键词: oxygen;prostaglandins;ductus arteriosus;calalase;superoxide;hydrogen peroxide;xanthine;oxidase

 

数据来源: OVID

 

摘要:

To determine whether oxygen metabolites can cause ductus relaxation, we used rings of fetal ductus obtained from 36 near-term lambs and measured the effects of the oxygen metabolites generated by the combination of hypoxanthine and xanthine oxidase. The oxygen metabolites produced by hypoxanthine plus xanthine oxidase caused relaxation of the ductus that was inhibited by catalase (hydrogen peroxide scavenger) but not by superoxide dismutase (superoxide anion scavenger). In addition, hypoxanthine plus xanthine oxidase produced a 14-fold increase in prostaglandin (PG) E2production with only twofold increase in 6-keto-PGFla(the stable metabolite of PGI2). PGE2is the most potent relaxant of the ductus arteriosus. The presence of either catalase or indomethacin blocked both the increase in prostaglandin production and the relaxation. We conclude that reactive oxygen metabolites relax the ductus arteriosus and oppose the normal constriction that occurs after birth. However, the vasoactive effects of reactive oxygen metabolites in the ductus appear to be mediated exclusively through the generation of PGE2.

 

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