Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light
作者:
Robert F. Furchgott,
Desingaro Jothianandan,
期刊:
Journal of Vascular Research
(Karger Available online 1991)
卷期:
Volume 28,
issue 1-3
页码: 52-61
ISSN:1018-1172
年代: 1991
DOI:10.1159/000158843
出版商: S. Karger AG
关键词: Endothelium-dependent vasodilation;Endothelium-independent vasodilation;Endothelium-dependent relaxing factor;Nitric oxide;Carbon monoxide;Photorelaxation
数据来源: Karger
摘要:
The characteristics of carbon monoxide (CO)-induced, endothelium-independent relaxation of rabbit aorta were compared with those of nitric oxide (NO)-induced and light-induced relaxation and endothelium-dependent relaxation mediated by endothelium-dependent relaxing factor (EDRF). CO was less than one thousandth as potent as NO as a relaxant. Various findings, including an increase in cyclic GMP associated with CO-induced relaxation, led to the conclusion that CO – like NO, EDRF and light – produces relaxation as a result of its stimulation of guanylate cyclase. LY 83583, which generates superoxide, was a potent, fast-acting inhibitor of acetylcholine-induced endothelium-dependent relaxation and NO-induced relaxation, and a fairly potent, moderately fast-acting inhibitor of photorelaxation, but only a very weak inhibitor of CO-induced relaxation. The ability of LY 83583 as well as hemoglobin to inhibit photorelaxation is consistent with the hypothesis that on radiation a photo-induced relaxing factor is formed which can stimulate guanylate cyclase and which can be inactivated by superoxide and by hemoglo
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