Tyrosine kinases are required for IFN γ‐induced growth of human embryonic forebrain astrocytes
作者:
Alyaa Mousa,
Ake Seiger,
Moiz Bakhiet,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 18
页码: 4097-4101
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Embryonic astrocytes;Forebrain;Human;IFN-γ;Stat-1;TPK
数据来源: OVID
摘要:
THE cytokine IFN-γ was shown to regulate growth and differentiation of human embryonic forebrain astrocytes. This work investigated a signalling pathway used by IFN-γ during the process of growth regulation of human fetal astrocytes obtained from first trimester embryos. IFN-γ induced significantly higher cell survival compared to that of unexposed cultures, and this survival could be suppressed by incubation with the tyrosine protein kinase (TPK) specific inhibitor tyrphostin A47 at the non-toxic concentration of 10-6M. The signal transducer and activator of transcription (STAT)-1 was translocated into the nucleus upon IFN-γ stimulation, which was also blocked by incubation with A47. Our data demonstrate that TPKs are actively involved in growth regulation of the developing brain astrocytes induced by IFN-γ.
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