Role of Akt Signaling in Vascular Homeostasis and Angiogenesis
作者:
Ichiro,
Shiojima Kenneth,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2002)
卷期:
Volume 90,
issue 12
页码: 1243-1250
ISSN:0009-7330
年代: 2002
出版商: OVID
关键词: Akt;endothelial cells;angiogenesis;statins;endothelial nitric oxide synthase
数据来源: OVID
摘要:
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.
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