Pulmonary biochemical effects of inhaled phosgene in rats
作者:
Serafino Franch,
GaryE. Hatch,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 19,
issue 3
页码: 413-423
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530939
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Three exposure regimens were used to study the time course of indicators of lung damage and recovery response to single or repeated exposures to phosgene (COCI2). Rats were sacrificed (1) immediately or throughout a 38‐d recovery period after inhalation of 7 ppm COCI2for 4 h, (2) at intervals during a 7‐h exposure to 1 ppm phosgene, or (3) at several time points throughout a 17‐d exposure to 0.125 and 0.25 ppm COCI2(4 h/d, 5 d/wk) and during a 21‐d recovery period. Regimen 7 revealed significantly elevated lung wet weight, lung nonprotein sulfhydryl (NPSH) content, and glucose‐6‐phosphate dehydrogenase (G6PD) activity that stayed elevated for up to 14 d. A significant decrease in body weight and food intake was observed 7 d after exposure. Regimen 2 caused a slight depression in NPSH content but did not affect G6PD activity. Regimen 3 animals showed sustained elevations in lung wet weight, NPSH content, and G6PD activity after 7 d of exposure. No significant changes in these endpoints were observed for the 0.125 ppm COCI2group. No consistent elevation in hydroxyproline content was seen at either exposure concentration. Light microscopic examination of lung tissue exposed to 0.25 ppm COCI2for 17 d revealed moderate multifocal accumulation of mononuclear cells in the centriacinar region. In summary, exposure to COCI2caused changes similar in most ways to those observed for other lower‐respiratory‐tract irritants.
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