NMR Methods for Optical Purity Determination of Pharmaceuticals
作者:
HassanY. Aboul-enein,
期刊:
Analytical Letters
(Taylor Available online 1988)
卷期:
Volume 21,
issue 12
页码: 2155-2163
ISSN:0003-2719
年代: 1988
DOI:10.1080/00032718808059899
出版商: Taylor & Francis Group
关键词: NMR spectroscopy - optical purity determination of pharmaceuticals;lanthanide shift reagents used in NMR determination of enantiomers of drug;Enantiomeric purity determination by NMR spectroscopy
数据来源: Taylor
摘要:
Although enantiomers normally have identical spectra, several methods for measurement of optical purity using NMR are possible: forming diastereomeric derivatives using chiral solvents and complexation with chiral reagents especially lanthanide shift reagents. The major limitation of these techniques as quantitative methods is the small chemical shift differences observed. However, with the availability of a wide range of lanthanide shift reagents, this problem is overcome. Several examples are cited for optical purity determinations of several pharmaceuticals using lanthanide shift reagents.
点击下载:
PDF (300KB)
返 回