Biochemical Properties of a Defective Hamster C-Type Oncornavirus
作者:
Kenneth D. Somers,
John T. May,
Saul Kit,
Kenneth J. McCormick,
George G. Hatch,
Wayne A. Stenback,
John J. Trentin,
期刊:
Intervirology
(Karger Available online 1973)
卷期:
Volume 1,
issue 1
页码: 11-18
ISSN:0300-5526
年代: 1973
DOI:10.1159/000148827
出版商: S. Karger AG
关键词: Hamster C-type oncornavirus;DNA polymerase deficiency;Defective hamster C-type oncornavirus
数据来源: Karger
摘要:
A noninfectious hamster C-type oncornavirus (D9) associated with a spontaneous hamster lymphoma was characterized. The defective virions contained 70S RNA and the base composition was similar to that of a murine sarcoma-leukemia virus. With both endogenous and added templates, the virions were found to be deficient in DNA polymerase activity. These results suggest that DNA polymerase may be required for D9 infectivity.
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