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Biochemical Properties of a Defective Hamster C-Type Oncornavirus

 

作者: Kenneth D. Somers,   John T. May,   Saul Kit,   Kenneth J. McCormick,   George G. Hatch,   Wayne A. Stenback,   John J. Trentin,  

 

期刊: Intervirology  (Karger Available online 1973)
卷期: Volume 1, issue 1  

页码: 11-18

 

ISSN:0300-5526

 

年代: 1973

 

DOI:10.1159/000148827

 

出版商: S. Karger AG

 

关键词: Hamster C-type oncornavirus;DNA polymerase deficiency;Defective hamster C-type oncornavirus

 

数据来源: Karger

 

摘要:

A noninfectious hamster C-type oncornavirus (D9) associated with a spontaneous hamster lymphoma was characterized. The defective virions contained 70S RNA and the base composition was similar to that of a murine sarcoma-leukemia virus. With both endogenous and added templates, the virions were found to be deficient in DNA polymerase activity. These results suggest that DNA polymerase may be required for D9 infectivity.

 

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