In Vivo Modulation of Murine Collagen Induced Arthritis
作者:
RangesGerald E.,
FortinSusan,
BargerMichael T.,
SriramSubramaniam,
CooperSheldon M.,
期刊:
International Reviews of Immunology
(Taylor Available online 1988)
卷期:
Volume 4,
issue 1
页码: 83-90
ISSN:0883-0185
年代: 1988
DOI:10.3109/08830188809044772
出版商: Taylor&Francis
关键词: collagen-induced arthritis;anti-CD4 antibodies;cell transfer
数据来源: Taylor
摘要:
The effects of in vivo modulation of murine collagen induced arthritis with monoclonal anti-CD4 antibodies, monoclonal anti-la antibodies, and gamma interferon are reviewed. We detail the mechanism of action of monoclonal anti-CD4 antibody on humoral and cell mediated immune responses and discuss the implications for designing therapeutic strategies. To further explore the induction of collagen induced arthritis, a syngeneic cell transfer system using collagen primed T lymphocytes is described. This cell transfer system provides an opportunity to study the role of CD4 positive T lymphocytes in arthritis induction during a short, defined time period.
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