Melatonin Effects in a Patient with Severe REM Sleep Behavior Disorder: Case Report and Theoretical Considerations
作者:
Dieter Kunz,
Frederik Bes,
期刊:
Neuropsychobiology
(Karger Available online 1997)
卷期:
Volume 36,
issue 4
页码: 211-214
ISSN:0302-282X
年代: 1997
DOI:10.1159/000119383
出版商: S. Karger AG
关键词: Actigraphy;Melatonin;Motor activity;Parasomnia;REM sleep
数据来源: Karger
摘要:
REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed diagnosis of RBD with 3 mg melatonin, which led to a significant reduction of motor activity during sleep, as measured by actigraphy (p < 0.0001 in all analyzed movement parameters), and a full clinical recovery over a 5-month treatment period. RBD phenomena gradually returned after melatonin administration was stopped. After 2 months’ treatment, polysomnography showed no major changes except an increase of REM sleep (13 vs. 17% of sleep period time) and a better preservation of REM-sleep-associated muscle atonia. Our results suggest that melatonin might be able to reinforce REM sleep in RBD patients by enhancing its active inhibition of motor activit
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