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High Affinity and Selectivity of Some Tetrahydroprotoberberine Alkaloids for Rat Striatal3H-raclopride Binding Sites

 

作者: Diego Cortes,   Jeannette Arbaoui,   Philippe Protais,  

 

期刊: Natural Product Letters  （Taylor Available online 1993）
卷期: Volume 3, issue 3  

页码: 233-238

 

ISSN:1057-5634

 

年代: 1993

 

DOI:10.1080/10575639308043869

 

出版商: Taylor & Francis Group

 

关键词: Tetrahydroprotoberberine alkaloids;3H-SCH 23390;3H-raclopride;binding;dopamine D1and D2receptors;3H-dopamine uptake

 

数据来源: Taylor

 

摘要:

Four tetrahydroprotoberberine alkaloids isolated fromGuatteria ouregouandGuatteria schomburgkianawere tested for their ability to displace3H-SCH23390 and3H-raclopride from their specific dopaminergic striatal binding sites and to inhibit3H-dopamine uptake by striatal synaptosomes. All of them displaced3H-raclopride binding with a high affinity and a great selectivity. These data suggest that the tetrahydroprotoberberine skeleton could be very interesting for developing selective ligands of D2dopamine receptors.

 

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