Aldosterone in renal disease
作者:
Hassan Ibrahim,
Thomas Hostetter,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 2003)
卷期:
Volume 12,
issue 2
页码: 159-164
ISSN:1062-4821
年代: 2003
出版商: OVID
关键词: aldosterone;remnant kidney model;proteinuria
数据来源: OVID
摘要:
Purpose of reviewInterruption of the renin-angiotensin-aldosterone system, chiefly with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, has yielded beneficial results in retarding injury and progression in numerous intrinsic renal diseases. The renoprotection offered by these agents is incomplete and far from optimal. Studying mediators of progression other than angiotensin II is therefore extremely important. The emerging role of aldosterone in progression of renal disease and the utility of its antagonism is discussed here.Recent findingsThe experimental evidence linking aldosterone to renal disease is discussed. The exciting results from clinical studies employing mineralocorticoid receptor blockers are also described.SummaryAldosterone antagonism offers additional antiproteinuric benefits to those achieved with angiotensin-converting enzyme inhibition. Long-term trials addressing effectiveness and safety, especially in regards to hyperkalemia, are greatly needed.
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