Estimation of Plasma Tacrine Concentrations Using An In Vitro Cholinesterase Inhibition Assay
作者:
Pamela Moriearty,
William Kenny,
Vinod Kumar,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1989)
卷期:
Volume 3,
issue 3
页码: 143-147
ISSN:0893-0341
年代: 1989
出版商: OVID
关键词: Tacrine;Cholinesterase;Inhibition assay;9-amino, 1, 2, 3, 4-tetrahydroacridine
数据来源: OVID
摘要:
THA (9-amino, 1,2,3,4-tetrahydroacridine; tacrine) is currently under study as a cholinesterase (ChE) inhibitor in Alzheimer disease. In this study, a sensitive radiometric assay for THA inhibition of human plasma ChE, suitable for detection of effects of orally administered drug, is described. The assay is sensitive in a range of 4–50 ng/ml plasma. Reversibility of the inhibition permits distinguishing of drug effects on ChE from changes in amount of enzyme synthesized during treatment.
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