Efficacy of Itraconazole in the Prevention of Fungal Infections Among Neutropenic Patients with Hematologic Malignancies and Intensive Chemotherapy. A Double Blind, Placebo Controlled Study
作者:
VreugdenhilGerard,
Van DijkeBeatrix J.,
DonnellyJ. Peter,
NovakovaIrena R. O.,
RaemaekersJohn M. M.,
HoogkampMieke A. A.,
KosterMarijke,
De PauwBen E.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 11,
issue 5-6
页码: 353-358
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309067926
出版商: Taylor&Francis
关键词: Itraconazole;neutropenia;leukemia;fungal infection;prophylaxis
数据来源: Taylor
摘要:
We studied the efficacy and safety of itraconazole for the prevention of fungal infection in neutropenic patients given cytotoxic chemotherapy for hematologic malignancies. Patients were randomly allocated to receive either itraconazole (200 mg bd) or placebo in addition to oral amphotericin B until the patient either developed fungal infection or had completed an-tileukemic treatment. Forty six patients (83 neutropenic episodes) treated with itraconazole and 46 placebo treated patients (84 neutropenic episodes) were evaluable. No specific toxicity was noted. Nine fungal infections developed in the itraconazole group, of which four were histologically or microbiologically proven and 15 in the patients given placebo (eight proven) (p>0.12). All these patients received IV amphotericin B. The incidence of Candida albicans infections tended to be lower in the itraconazole group, but overall, there was no measurable improvement in the prevention of fungal infections and mortality by itraconazole.
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