Carnitine Action on Neuromuscular Disturbances in the Fasting Rat: Potentiation byL-Lysine
作者:
Gilles Pierrefiche,
Michel Reynier,
Henri Laborit,
期刊:
Pharmacology
(Karger Available online 1993)
卷期:
Volume 46,
issue 1
页码: 33-42
ISSN:0031-7012
年代: 1993
DOI:10.1159/000139026
出版商: S. Karger AG
关键词: L-Carnitine;L-Lysine;Neuromuscular functions;Fasting;Rat
数据来源: Karger
摘要:
L-Carnitine (oral route) signiñcantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxifying agent of intracellular acyl-CoA. The activity of L-carnitine is increased with the concomitant administration (oral route) of an equimolar dose of L-lysine. In the present experimental conditions, there is a threefold potentiation by comparison with L-carnitine alone. This result is discussed on the basis of the combined effects of an exogenous supply of L-carnitine and endogenous synthesis of L-carnitine from the L-lysine administered at the same time
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