The effect of methanol extraction residue of BCG on the cellular immune response in patients with malignant melanoma
作者:
Arie Bartal,
Yoram Cohen,
Tamar Mekori,
Robert Haasz,
E. Robinson,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1979)
卷期:
Volume 6,
issue 1
页码: 1-10
ISSN:0098-1532
年代: 1979
DOI:10.1002/mpo.2950060102
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: malignant melanoma;MER;immunotherapy
数据来源: WILEY
摘要:
AbstractTwenty‐one patients with malignant melanoma stage III and IV were treated by intradermal injections of MER ‐ methanol extraction residue of Baccillus Calmette‐Gurin (BCG). Twelve of the patients, all with active disease, received chemotherapy in addition. Tests of skin reactivity to recall antigens and in vitro lymphocyte transformation by phytohemagglutinin (PHA), purified protein derivative (PPD), Canadidine, and Varidase were performed in 19 of the patients before and after the MER therapy. The skin reactivity improved in 8 patients, 5 patients maintained their cutaneous competence, 3 remained incompetent, and in 3 other patients a decrease in reactivity occurred. Improvement or maintenance of cutaneous response was more common in stage III than in stage IV patients. The in vitro lymphocyte stimulation tests have shown that reactivity increased or remained at a high level in 9 of 11 patients in stage III. It dropped or remained low in 2 patients in respect to all antigens used in spite of repeated MER injections. In most patients with stage IV disease no improvement could be detected. MER seems to be a potent immunostimulator in patients in stage III. The side effects were tolerable in all patients and consisted of local reactions and influenza‐like symptoms. In 4 patients treated with MER by intralesional injections, transiet flattening of nodules occurred but no complete regression was o
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