Inherited Deficiency of Antithrombin III in Two Italian Families
作者:
C. Manotti,
R. Quintavalla,
A. Megha,
O. Ponari,
A.G. Dettori,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1982)
卷期:
Volume 12,
issue 3
页码: 300-308
ISSN:1424-8832
年代: 1982
DOI:10.1159/000214687
出版商: S. Karger AG
关键词: Antithrombin III congenital defect;Acenocoumarin treatment
数据来源: Karger
摘要:
A significant decrease of plasma antithrombin III (AT III) levels, measured with four different biological and immunological methods, was found in 8 of 11 members of a Sicilian family (family DM) and in 3 of 14 members of a northern Italian family (family A). Different behaviour after oral anticoagulant treatment with acenocoumarin was seen in 2 long-term treated subjects. The propositus of family DM, who had had a long history of recurrent thrombosis, did not show any increase of AT III levels. A significant increase was, on the contrary, observed in the propositus of family A, who had suffered a recent thrombosis in a branch of the inferior mesenteric vein.
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