Differences in the expression of histocompatibility antigen‐DR and in anti‐Mycobacterial activity of monocytes from HIV‐infected individuals
作者:
Bruce Zwilling,
Janelle Salkowitz,
Harry Laufman,
Dennis Pearl,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 11
页码: 1327-1332
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Histocompatibility antigen-DR expression;HIV;monocytes;Mycobacterium avium;tuberculosis
数据来源: OVID
摘要:
This study assesses the changes in the expression of histocompatibility antigen (HLA)-DR by mononuclear phagocytes from HIV-infected individuals. Overnight culture of monocytes resulted in an increase in HLA-DR expression by monocytes from uninfected individuals. In contrast, the expression of HLA-DR by monocytes from HIV-infected patients decreased spontaneously and was most pronounced in patients with clinical AIDS. We also found thatMycobacterium aviumgrew within monocytes from patients infected with HIV. The correlation between major histocompatibility complex (MHC) class II expression and Mycobacterial growth which has been reported in mice was not observed in monocytes from HIV-infected patients.
点击下载:
PDF
(493KB)
返 回