Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset
作者:
Isabelle Gourfinkel-An,
Geraldine Cancel,
Charles Duyckaerts,
Baptiste Faucheux,
Jean-Jacques Hauw,
Yvon Trottier,
Alexis Brice,
Yves Agid,
Etienne Hirsch,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1823-1826
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Huntington's disease;Intranuclear inclusions;Postmortem brain;Ubiquitine
数据来源: OVID
摘要:
NEURONAL intranuclear inclusions were recently found in the brain of patients with inherited neurodegenerative disorders characterized by the expansion of a polyglutamine stretch in the mutated protein. These inclusions are ubiquitinated and, for some of these diseases, the presence of the mutated protein could be also identified. Using immunohistochemistry, we show here that ubiquitinated intranuclear inclusions are also observed postmortem in the brain of patients suffering from Huntington's disease characterized by small polyglutamine expansions and adult onset. We were, however, unable to detect the mutated form of huntingtin in these inclusions. These intranuclear inclusions were detected only in the affected cerebral regions, suggesting that their presence is probably linked to the neurodegenerative process.
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